We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This book is not only a major twentieth-century contribution to Dostoevsky’s studies, but also one of the most important theories of the novel produced in our century. As a modern reinterpretation of poetics, it bears comparison with Aristotle.“Bakhtin’s statement on the dialogical nature of artistic creation, and his differentiation of this from a history of monological commentary, is profoundly original and illuminating. This is a classic work on Dostoevsky and a statement of importance to critical theory.” Edward Wasiolek“Concentrating on the (...) particular features of ‘Dostoevskian discourse,’ how Dostoevsky structures a hero and a plot, and what it means to write dialogically, Bakhtin concludes with a major theoretical statement on dialogue as a category of language. One of the most important theories of the novel in this century.” The Bloomsbury Review. (shrink)

The article is devoted to the problem of the naming crisis of modern society. The sequences by which the social and cultural history of the West is ordered, represented by the evolution of economics, technology, religion, forms of capital and wealth, communications, following the technological acceleration of time, coexist with each other, compete for primacy, creating a society of atomized subjects who have ceased to understand their place in the history of society. This situation is described in the article as (...) an identity crisis. The purpose of this work is to demonstrate the gaps that have been discovered in attempts to identify society, which are the object of criticism. The article refers to the tradition of explanatory modeling of social interactions in terms of psychopathology and psychiatry. The crisis of the identity of society is illustrated through the images of madness in modern art culture. The article hypothesizes that there is an unspoken ban on naming a society associated with the crisis of capitalism in the transition from disciplinary societies to control societies. Culture's interest in insanity serves as an indicator of a social crisis. The evolution of cultural interest in the figure of a madman from a frightening "outcast" to an attractive "rebel" is shown. The article suggests the tasks of critical philosophy that coincide with the tasks of caring for social health. The idea of the need for the deprivation of mental illness is expressed. Mental health care is considered as a social task. (shrink)

The article discusses the importance of strength training in the training process and its impact on the technical skills of athletes. The use of strength exercises during training sessions and rational planning of strength training in the training process are considered. Practical and methodological recommendations are given on the use of various strength physical exercises to improve the technique of basic competitive movements. Examples of the use of various physical loads during certain exercises in order to improve the technical readiness (...) of athletes are shown. (shrink)

In the existing philosophical interpretations of mystical experience (constructivism, essentialism, etc.), its essence is usually seen in the features of "mystical knowledge". At the same time, the value-semantic foundations of mystical experience and its existential aspect remain in the shadows. In this article, the mystical experience is analyzed from the standpoint of the theories of the subject's objective activity - the theory of activity (developed in Russian psychology), enactivism, and the concept of the "life world". It is shown that the (...) essence of mystical experience is manifested not in cognitive, but in value-semantic, existential attitude to the world, which is represented by two groups of value-semantic viewpoints. In the first, the dependence of the subject on the sacred object of mystical experience is expressed, in the second - the volitional focus of the subject on overcoming such dependence, "mastering", "acquiring" the sacred object. These attitudes reflect the duality of the need-motivational sphere of consciousness, which gives the activity of the subject, on the one hand, activity, energy, and on the other, meaning. In mystical experience, the subject of active "development", "acquisition" (which can be both real and virtual) is an imaginative "otherworldly reality". The analysis allows us to conclude that mystical experience is one of the forms of motivational states of consciousness. Its peculiarity is that it is aimed at realizing the need for the harmonization of the subject's relations with the natural and social environment, the subject's finding the meaning of the "existence of his self" in an always open to the future, incomplete life world. It is the motivational basis that gives the mystical experience an improvisational character, as well as a creative, renewing potential (within the boundaries of the sensory-emotional experience of the world by the subject). The article also analyzes the concept of semantic reality. It is shown that the semantic foundations of mystical experience reflect the individually unique aspects of human life, are the result of the interactions of many factors of socio-cultural, individual-personal nature (psychological, medical, pharmacological, gender, psychiatric, etc.). (shrink)

The article examines some aspects of Brentano's ontology, starting with his 1862 dissertation "On the ambiguity of Being according to Aristotle", as well as its influence on the philosophy of M. Heidegger. The author shows that the ontology of the early Brentano is not limited to ousiology, since it includes a discussion of the field of mental being (ens rationis, ὂν ὡς ἀληθές) and it is in this aspect that he influences the young Heidegger. Following Aristotle, Brentano assigns a central (...) role to the ontology of essence, which in the late period leads him to the position of reism, but in the lectures of the middle period Brentano discusses the problems of intentional inexistence, thanks to which projects of "new types of ontology" by Husserl and Mainong appear. The author believes that Heidegger was also influenced by these ideas. Of course, there are fundamental differences between the positions of Brentano and Heidegger, but the similarities are quite large. In particular, if Brentano, highlighting the real and true areas, gives preference in favor of the former, then Heidegger's ontology is built on the second member of this opposition. In particular, everything that can be given is called being by Heidegger, because we are talking about intentional being, about ens rationis, or ὂν ὡς ἀληθές. (shrink)

The article deals with Heidegger’s interpretation of antique ontology, in which Being was conceptualized in terms of production. What is this interpretation and why is it so important? Until recently, it has been difficult to answer these questions, since the texts in question have only in recent years become publicly available, and therefore have not yet been fully absorbed in Heideggerian-studies. Consequently, even the very useful works that cover the subject of production-theme in Heidegger focus more on the question of (...) technique and do not consider the formation of this problematic, and therefore do not deal with it substantively. In the years 1921-1924, Heidegger was closely involved with Aristotle and lectured on his favorite philosopher for four years. It was during this period that he began to interpret Being in Aristotle as being-made, being-produced (das Hergestelltsein), and then extended this interpretation to the whole of ancient and medieval philosophy. This is a very remarkable moment in terms of methodology that characterizes Heidegger as a historian of philosophy. In this article, the author examines Heidegger’s interpretation of ancient ontology, revealing its weaknesses. (shrink)

The responsibility of the subjects is the most important basis of the social life. Recurrences of irresponsible behaviour on the all levels of the modern society do the problem of the purposeful cultivation of the liberty and the morality to be more actual nowadays. The liberty and the morality realized by any personality become the prerequisites of the responsibility that are so necessary for the society. Became the true reality the responsibility provides the sustainable reproduction of all system of feelings, (...) convictions and actions and raises the liberty to the higher and more deliberate stage. Responding to the changes of the time the philosophy has to be urged to clarify the idea of the closing of the social anthropology, aksiologiya and ethics. (shrink)

The question of constructing an evolutionary picture of the world based on the results obtained by extending classical mechanics is considered. The expansion of mechanics arose as a result of taking into account the role of the structure of bodies in their dynamics. It is shown that such an extension leads to the possibility of combining branches of physics, in particular, to the substantiation of the laws of thermodynamics, statistical physics, kinetics within the framework of the laws of classical mechanics. (...) It turned out that, according to the laws of classical mechanics, matter is infinitely divisible and can be represented by an infinite hierarchical structure from simple to complex. The expansion showed the existence of universal principles connecting the laws of the upper rung of the hierarchical ladder of matter with the laws of the lower rung. It is considered how they lead to the possibility of constructing a picture of the world based on the fundamental laws of nature. (shrink)

The subject of the research is utopian discourse, which unites all the variety of concepts related in one way or another to utopia, utopian dimension of reality and understanding of the Future (utopian element, utopian impulse, utopian optics, utopianism, utopian consciousness, utopian thinking, dystopia, etc.). Special attention is paid to the study of the explanatory and predictive potential of utopian discourse, identifying its boundaries and analysis of the relationship with ideological discourse. The conceptualization of utopian discourse is based on an (...) instrumental approach to utopia, which is complemented by the communicative approach and the interpretive concept of culture by K. Geertz, which justifies the possibility of considering utopian discourse as a semantic and symbolic matrix. The novelty of the research is to identify and substantiate the exaggerated dichotomy of thinking and otherness as the structure-forming elements of utopian discourse. This contributed to the assessment of utopian discourse as a peculiar but viable form of reflection of political reality and the construction, consolidation and comprehension of values. The proposed algorithm of thinking with dichotomies made it possible to trace the process of constructing utopian discourse on the basis of a pyramid of dichotomies, consisting of system-forming, key and peripheral dichotomies. The article clarifies that the otherness of utopian discourse is manifested in the historicity, radicality and inextricable connection of utopian discourse with the Present. The indicated specificity of utopian discourse has led to the clarification of the reasons for the negative and/or skeptical attitude towards utopia and utopian discourse, as well as to the definition of its strengths and weaknesses. The authors conclude that despite the identified shortcomings, which often lead utopias to periodic displacement from the framework of actual political life, utopian discourse can have a significant impact on the change and development of society. (shrink)